Click Chemistry: 1,2,3-Triazoles as Pharmacophores
نویسندگان
چکیده
منابع مشابه
Click chemistry: 1,2,3-triazoles as pharmacophores.
The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to pr...
متن کاملMedicinal and Biological Importance of 1,2,3-Triazoles in Click Chemistry
In this study, 1,2,3-Triazole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities. There is a growing demand for the preparation of new antimicrobial agents due to the developing resistance towards conventional antibiotics, 1,2,3-Triazoles are an important class of organic compounds due to their wide applications in the synthesis of pharmaceuti...
متن کاملSynthesis of spiroacetal-triazoles as privileged natural product-like scaffolds using "click chemistry".
The elaboration of a 6,6-spiroacetal scaffold to incorporate a triazole unit as a peptide bond surrogate at the anomeric position is described. The novel spiroacetal-triazole hybrid structures were generated via cycloaddition of a spiroacetal azide to a series of alkynes. The spiroacetal framework was constructed via Barbier reaction of bromide 10 with Weinreb amide 11, followed by acid-catalys...
متن کاملA versatile new monomer family: functionalized 4-vinyl-1,2,3-triazoles via click chemistry.
Using facile, highly modular synthetic approaches, a new monomer family based on a 1,2,3-triazole-4-vinyl building block has been prepared, and various functional derivatives have been obtained. Subsequent homo- and copolymerization of these novel functionalized monomers gives polymeric materials with unique physical properties, combining many attractive features of more traditional monomers, s...
متن کاملExpanding the Scope of Cu(I) Catalyzed “Click Chemistry” with Abnormal NHCs: Three-Fold Click to Tris-Triazoles
Cationic copper(I) complexes [Cu(aIPrPh)(IPr)]I (3) and [Cu(aIPr)2]I (4) featuring an abnormal N-heterocyclic carbene (aNHC) (aIPrPh = 1,3-bis(2,6-diisopropylphenyl)-2-phenylimidazol-4-ylidene) and/or an NHC (IPr = 1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene) ligand(s) are reported. Treatment of Cu(aIPrPh)I (2) with IPr affords complex 3. Reaction of (IPrPh)I (1) (IPrPh = 1,3-bis(2,6-diiso...
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ژورنال
عنوان ژورنال: Chemistry - An Asian Journal
سال: 2011
ISSN: 1861-4728
DOI: 10.1002/asia.201100432